Tumefactive multiple sclerosis presenting with tonic-clonic seizure.

To cite: Idris AA, Begum T, Verlage KR, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2016215266 DESCRIPTION A 37-year-old Hispanic man with no medical history presented with sudden onset of two episodes of witnessed seizure. On arrival to the emergency room, he experienced another episode of generalised tonic–clonic seizure witnessed by the physician and nurses. His seizure was accompanied by tongue biting and postictal confusion, but neither bowel nor bladder incontinence. Each episode lasted nearly 15–20 s and resolved without intervention. The patient did not have a similar event in the past and family history was negative for seizure disorder. He was not on medication at home and denied recreational drug use. On physical examination, he had postictal generalised weakness but no focal neurological deficit. An initial CT scan of the brain indicated low density focus on the left frontal lobe. Subsequent MRI reported a 2.4×2.2 cm well-circumscribed lesion with contrast enhancement with neither vasogenic oedema nor mass effect (figure 1, yellow arrow). Multiple white matter plaques were also noted (figure 1, green arrow). Lumbar puncture revealed clear cerebrospinal fluid (CSF) with 3 white cell counts and 0 red blood cell. CSF protein was 14 mg/dL and glucose, 66 mg/dL. CSF myelin basic protein was 16.3 ng/mL and eight oligoclonal band was observed in the CSF. All other infectious aetiologies were excluded. The patient was started on methylprednisone for 3 days and discharged with interferon β. Tumefactive multiple sclerosis (MS) is a clinical variant of MS, presenting as a mass-like lesion and often associated with oedema or ring enhancement. The demyelinating areas in the brain are usually large (>2 cm) lesions mimicking a large tumour. There may be mass effect with compression of the lateral ventricle and midline shift. The radiological differential diagnoses of such lesions are brain abscess, primary central nervous system (CNS) tumour—glioma or astrocytoma, metastatic lesion from a distal primary tumour, toxoplasmosis and CNS lymphoma, etc. The clinical presentation varies from an asymptomatic incidental finding to confusion, seizure, hemiparesis or hemi-neglect syndrome. In a previously described large case series, the median age at onset was 37 years (range 8–69). The patients presented with different motor, cognitive, sensory and cerebellar symptoms. The lesions on the brain were often multifocal, and frequently had ring enhancement with a heterogeneous or homogeneous appearance on gadolinium-enhanced MRI. Nearly 50% of the cases had a relapsing-remitting course. There is no variation in the treatment protocol for this particular variant of MS.